Endocrine Abstracts

Introduction: Excess GH in acromegaly has lipolytic action and detrimental effect on glucose metabolism and insulin signaling. Recent studies have suggested a specific lipodystrophy in patients with acromegaly. Paradoxically, although the visceral adipose tissue (VAT) and intrahepatic lipid were reduced in active acromegaly compared to controls, insulin resistance was increased. Fat was redistributed from subcutaneous and visceral depots to muscle; weight and VAT depots rose w...

Introduction: Treatment options for acromegaly include surgery or radiation to remove or reduce the size of the tumor and medication to help normalize the hormone levels. While improving the prognosis, patients with acromegaly treated with radiotherapy are at risk of long-term development of secondary malignancies (1-2% at 10-20 years). We report the case of a 55-year old woman diagnosed with high-grade sarcoma of the sphenoid sinus developed 34 years after receiving 60Cobalt ...